Anthropic’s CEO gives ‘a 25% chance things go really, really badly’ with AI

• September 20, 2025

• Anthropic CEO Dario Amodei estimates a 25% chance AI leads to catastrophe
• He still believes AI is worth investing in and that the benefits outweigh the risks
• His comments fit with growing public and policy conversations about AI risks and regulation

One-in-four odds might seem pretty good in some circumstances. It’s way better odds than most casino games, for instance. However, it’s apparently unlikely enough for Anthropic CEO Dario Amodei to seem unconcerned after pegging the chance that artificial intelligence leads to a society-ending disaster at 25%.

“I think there’s a 25% chance that things go really, really badly,” Amodei blithely said at the Axios AI + DC Summit when asked about his (p)doom – probability of doom – belief around AI. But he’s more focused on the “75% chance that things go really, really well.”

By “really, really badly,” he doesn’t mean your phone autocorrecting “duck” to something worse. He means scenarios large enough to threaten societal systems, existential risks, badly misused AI, and runaway outcomes that could be catastrophic.

For an industry often drenched in utopian promise or reduced to sci-fi fearmongering, Amodei’s attitude about both the odds of an apocalypse and why he still is pushing forward with the technology did stand out.

Amodei isn’t alone in expressing unease, but he’s in a rarified position. As CEO of the company behind Claude, he’s not a passive observer. He’s shaping the trajectory of this technology in real time. His team is building the very systems whose potential and peril he’s weighing.

If someone told you there was a 1-in-4 chance your car would explode every time you turned the key, you might start walking more. Amodei would apparently become a mechanic and check the car out first before getting in.

AI doom

This also isn’t the only warning issued by Amodei about AI. He’s warned before that AI could eliminate half of all entry-level white-collar jobs and sounded the alarm against U.S. exports of high-end chips to China. That’s what makes Amodei’s framing so useful. It acknowledges the risk, quantifies the uncertainty, but leaves room for agency.

On the flip side, Amodei’s “75% chance things go really well” isn’t optimism for its own sake. It implies the belief that AI could produce enormous benefits for everyone. It could lead to improved medicine, more efficient manufacturing, and perhaps even strategies to address existential crises like climate change (though one key element to solving this might be the energy required for AI models to run).

But the 25% risk demands that those benefits be built carefully, with consideration for safety measures and regulation. Because if the future is 75% brilliant and 25% broken, the question is: What are we going to do to keep the weight on the right side?

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Anthropic CEO Dario Amodei estimates a 25% chance AI leads to catastrophe He still believes AI is worth investing in and that the benefits outweigh the risks His comments fit with growing public and policy conversations about AI risks and regulation One-in-four odds might seem pretty good in some circumstances.…