As long as you have a powerful PC to run it, then yes. Since its release in March 2020, there’s been efforts to make it run on non-VR devices, but these miss the point in how well VR works with Half Life: Alyx, and how its also helped in justifying the category.
If you do have a PC to run it, you’ll have no issue in streaming the game on your Oculus Quest 2. But just in case, here’s the system requirements:
OS: Windows 10
Processor: Core i5-7500 / Ryzen 5 1600
Memory: 12 GB RAM
Graphics: GTX 1060 / RX 580 – 6GB VRAM